![]() The obesity pill that could replace exercise by turning 'bad' fat to 'good'A team of scientists have identified a hormone causes a person to pile on weight, triggering obesity and type 2 diabetes. The study found obese people have higher levels of the hormone serotonin in the blood. The hormone inhibits the beneficial effects of brown fat - the 'good' fat that can be burned off - activity. Brown adipose tissue, known as brown fat, is located around the collarbone and acts as the body's furnace, burning calories to keep the body warm. Obese people have lower levels of brown fat, and its activity decreases with age. But until now, scientists have not known why. The study by Mc. Master University in Ontario, Canada, found there are two different types of serotonin. Scientists at Canada's Mc. Master University found obese people have higher levels of the hormone serotonin in the blood (picture posed by model)One type is found in the brain or central nervous system affects mood and appetite, but makes up only five per cent of the body's serotonin. The lesser- known peripheral serontonin circulates in the blood, and makes up 9. Mc. Master scientists discovered that this kind of serotonin reduces brown fat activity, or 'dials down' the body's metabolic furnace. The study, published in Nature Medicine, is the first to show blocking the production of peripheral serotonin makes brown fat more active. Professor of medicine Gregory Steinberg, said: 'Our results are quite striking and indicate that inhibiting the production of this hormone may be very effective for reversing obesity and related metabolic diseases including diabetes'Too much of this serotonin acts like the parking brake on your brown fat. You can step on the gas of the brown fat, but it doesn't go anywhere.'And the scientists believe they may also have identified the culprit responsible for elevated levels of peripheral serotonin - high- fat Western diets. Associate professor of pathology and molecular medicine Waliul Khan, added: 'There is an environmental cue that could be causing higher serotonin levels in our body and that is the high- fat western diet.'Too much serotonin is not good. We need a balance. If there is too much, it leads to diabetes, fatty liver and obesity.'The hormone, a model of which is pictured, inhibits the beneficial effects of brown fat - the 'good' fat that can be burned off - activity. The majority of serotonin in the body is produced by tryptophan hydroxylase (Tph. The study found that when they genetically removed or inhibited this enzyme that makes serotonin, mice fed a high- fat diet were protected from obesity, fatty liver disease and pre- diabetes due to an enhanced ability of the brown fat to burn more calories. Inhibiting the peripheral serotonin doesn't affect the serotonin in the brain or central nervous system functioning. This is in contrast to earlier weight loss drugs which worked to suppress appetite by affecting levels of brain serotonin, but were associated with problems including cardiac complications and increased risk of depression and suicide. ![]() ![]() Professor Steinberg said: 'Moving forward, we think it's a much safer method to work with increasing energy expenditure instead of decreasing the appetite, which involves more risks.'The researchers conclude that reducing the production of serotonin by inhibition of Tph. The Pros and Cons of 4 Trendy Diets. Day Diet. The 1. 7- Day Diet is apparently backed by Dr. And unlike what its name implies, the entire diet isn’t 1. In cycle 1, called. For example, in phase 2. Also, the total daily calorie allotment from the meal. ![]() ![]() ![]() ![]()
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